Title: NEW GENERATION OF BIOACTIVE LASER TEXTURED TI/HAP IMPLANTS
Acronym: BiLaTex
start-end date:
01/05/2023 – 30/04/2026
Total Project Costs: 765 000 (Euro)
Acknowledgements: The partners gratefully acknowledge financial support of the project “New Generation of Bioactive Laser Textured Ti/Hap Implants” under acronym “BiLaTex” carried out within M-ERA.NET 3 Call 2022 programme.
Project co-financed by the National Center for Research and Development under the program M-ERA.NET 3 Call 2022 under registration number ERA.NET3/2022/48/BiLaTex/2023.
Project Abstract
Visible effects of society’s ageing is the reported increase in the necessity of orthopaedic implants boosting to a huge economical market. For a successful integration of any implant, bone regeneration, osseointegration at the interface bone and implant as well as mitigating inflammatory events are crucial aspects. The project aims at extending the biocompatibility and tribo-mechanical performance associated with a lifetime of surgical implants based on Titanium (Ti). The hypothesis states combining Ti alloy with hydroxyapatite (HAp), and medically active components (drug delivery function) in order to obtain excellent biomaterial supporting bone growth and eliminating the problem of loosening of the implant by its integration with bone. The project goes beyond the state-of-the-art by laser surface treatment, opening the underlying porosity improving the cell transport and cell growth. The result implant biomaterial, will reduce the number of removal surgeries in the future.
Partners:
Coordinator – Cracow University of Technology (PK) ![]()
Contact person (Principal Investigator):
Dr inż. Agnieszka Maria Tomala
Faculty of Materials Engineering and Physics37 Jana Pawla II, 31-864 Cracow, Poland
Tel.: +48 12 628 34 62
e-mail: agnieszka.tomala@pk.edu.pl
Researchers Involved:
Prof. dr hab. inż. Agnieszka SOBCZAK-KUPIEC (agnieszka.sobczak-kupiec@pk.edu.pl),
dr hab. inż. Bożena Tyliszczak (bozena.tyliszczak@pk.edu.pl),
mgr inż. Julia Sadik (julia.sadlik@doktorant.pk.edu.pl),
mgr inż. Magdalena Bańkosz (magdalena.bankosz@pk.edu.pl) / mgr inż. Dominika Wanat (dominika.wanat@doktorant.pk.edu.pl)
mgr inż. Edyta Kosińska (edyta.kosinska@doktorant.pk.edu.pl)
Tallinn University of Technology (TalTech) ![]()
Contact person: DSc Irina Hussainova, Tenured Full Professor
Department of Mehanical and Industrial Engineering,
Tallinn University of Technology
Ehitajate 5, 19086, Tallinn, Estonia
Office: U06-205
Tel.: 372 6203371
e-mail: irina.hussainova@taltech.ee
Researchers Involved:
Dr. Rahul Kumar (rahul.kumar@taltech.ee) / Dr. Tatevik Minasyan (tatevik.minasyan@taltech.ee)
Dr. Mansoureh Rezapourianghahfarokhi (mansoureh.rezapourianghahfarokhi@taltech.ee )
University of Ljubljana (UL) ![]()
Contact person: University of Ljubljana
Faculty of Mechanical Engineering TINT – Laboratory for Tribology and Interface Nanotechnology
Aškerčeva 6, 1000 Ljubljana
Tel.: +386 1 4771 460
e-mail: Mitjan.Kalin@fs.uni-lj.si
Researchers Involved:
doc. dr. Marko Polajnar (marko.polajnar@fs.uni-lj.si)
ATMAT Sp. z o.o. (ATMAT) ![]()
Contact person: Mateusz Dyląg
ATMAT Sp. z o.o.
Ul. Leśna 28, 32-590 Libiąż
email: mateusz.dylag@atmat.pl
mobile: +48 501 256 670
Researchers Involved:
Jarosław Wołek (jaroslaw.wolek@atmat.pl)
Meetings:
1st kick-off meeting (on-line): 11.05.2023
2nd meeting (on-line): 28.09.2023
3rd meeting (on-line): 22.02.2024
4th meeting (on-line): 14.06.2024
5th meeting (at TalTech): 18-19. 09.2024
6th meeting (on-line): 10.01.2025
7th meeting (on-line): 28.04.2025
Download Meeting FILES
Publications:
1. Rezapourian, Mansoureh; Hussainova, Irina. Optimal mechanical properties of Hydroxyapatite gradient Voronoi porous scaffolds for bone applications — A numerical study. Journal of the Mechanical Behavior of Biomedical Materials, 2023, 106232, https://doi.org/10.1016/j.jmbbm.2023.106232
2. Kumar, R.; Rezapourian, M.; Rahmani, R.; Maurya, H.S.; Kamboj, N.; Hussainova, I. Bioinspired and Multifunctional Tribological Materials for Sliding, Erosive, Machining, and
2. Kumar, R.; Rezapourian, M.; Rahmani, R.; Maurya, H.S.; Kamboj, N.; Hussainova, I. Bioinspired and Multifunctional Tribological Materials for Sliding, Erosive, Machining, and
Energy-Absorbing Conditions: A Review. Biomimetics 2024, 9, 209.https://doi.org/10.3390/biomimetics9040209
3. Rezapourian, M., Kumar, R., & Hussainova, I. (2024). Effect of unit cell rotation on the mechanical performance of selective laser melted Gyroid structures for bone tissue
engineering. Progress in Engineering Science, 1(2-3), 100011. https://doi.org/10.1016/j.pes.2024.100011
4. Sadlik Julia, Edyta Kosińska, Magdalena Bańkosz, Agnieszka Tomala, Grzegorz Bruzda, Josef Jampilek, and Agnieszka Sobczak-Kupiec. "Gradient Titanium Alloy with Bioactive Hydroxyapatite Porous Structures for Potential Biomedical Applications" Materials, 2024, (17), 3.1.; https://doi.org/10.3390/ma17225511
5. Rezapourian, M., & Hussainova, I. (2025). Mechanical analysis of multi-surface TPMS lattices for bone applications. Proceedings of the Estonian Academy of Sciences, 74(2S), 222–227; https://doi.org/10.3176/proc.2025.2.25
6. Sadlik Julia, Edyta Kosińska, Agnieszka Tomala, Magdalena Bańkosz, Marko Polajnar, Rahul Kumar, Mitjan Kalin, Gaia Kravanja, Luka Hribar, Irina Hussainova, Marek Nykiel, Agnieszka Sobczak-Kupiec, Josef Jampilek "Effect of laser surface texturing and fabrication methods on tribological properties of Ti6Al4V/HAp biocomposites" Materials 2025, 18(11), 2468; https://doi.org/10.3390/ma18112468
Papers in progress:
- Multi-Task Neural Network-Based Estimation of Mechanical Properties in TPMS Lattices for Bone Implants (in the process of submission)
- Multi-Objective Optimization of TPMS Lattices Using Neural Networks and NSGA-II Targeting High Energy Absorption and Strength (will be submitted in Biomimetics (MDPI), end of May)
- Review paper: Optimization, Design, and Biocompatibility of TPMS in Bone Replacement: Bridging Mechanical and Biological Requirements (in progress)
Conferences & Symposia promoting the project:
1. Julia Sadlik “The Methods of Obtaining of Titanium-Hydroxyapatite Composites”, 32nd Annual Conference Biomaterials in Medicine and Veterinary Medicine, 12-15.X.2023r Rytro, Polska. plakat, https://www.biomat.agh.edu.pl/2023
2. Agnieszka Maria Tomala „HAp Powder as a Carrier of Biologically Active Substances”, 32nd Annual Conference Biomaterials in Medicine and Veterinary Medicine, 12-15.X.2023r Rytro, Polska. plakat, https://www.biomat.agh.edu.pl/2023
2. Agnieszka Maria Tomala „HAp Powder as a Carrier of Biologically Active Substances”, 32nd Annual Conference Biomaterials in Medicine and Veterinary Medicine, 12-15.X.2023r Rytro, Polska. plakat, https://www.biomat.agh.edu.pl/2023
3. Magdalena Bańkosz „Effect of Synthesis Parameters on Physicochemical Properties of Calcium Phosphates” 32nd Annual Conference Biomaterials in Medicine and Veterinary Medicine, 12-15.X.2023r Rytro, Polska. plakat, https://www.biomat.agh.edu.pl/2023
4. Julia Sadlik, Agnieszka Tomala, Edyta Kosińska, Agnieszka Sobczak-Kupiec, “Sustainable process of obtaining composites by powder metallurgy”, 4th International Conference Strategies toward Green Deal Implementations Water, Raw Materials & Energy, 14.12-15.12.2023, online, plakat, https://min-pan.krakow.pl/konferencje/en/iv-miedzynarodowa-konferencja-nt-strategii-wdrazania-zielonego-ladu-woda-surowce-i-energia-icgreendeal2023/
5. Magdalena Bańkosz, Julia Sadlik, Agnieszka Tomala “Obtaining Hydroxyapatite as a Calcium Phosphate with High Potential in Bone Tissue Engineering”, The 1st International Online Conference on Functional Biomaterials, 10.06-12.06.2024, online, plakat, https://sciforum.net/event/iocfb2024
6. Julia Sadlik, Agnieszka Tomala, Magdalena Bańkosz,“Sintering of Titanium-Ceramic Composites”, The 1st International Online Conference on Functional Biomaterials, 10.06-12.06.2024, online, plakat, https://sciforum.net/event/iocfb2024
7. Agnieszka Tomala, Julia Sadlik, Magdalena Bańkosz, “Gradient Ti/HAp Composite Biomaterials Fabricated by Controlled Thermodynamic Powder Metallurgy”, The 1st International Online Conference on Functional Biomaterials, 10.06-12.06.2024, online, plakat, https://sciforum.net/event/iocfb2024
8. Magdalena Bańkosz, Julia Sadlik, Edyta Kosińska, Agieszka Tomala,“Optimization of synthesis conditions of gradient composites for biomedical applications.”, 5th International Conference Strategies toward Green Deal Implementations Water, Raw Materials & Energy, 27.11-29.11.2024, online, plakat https://www.greendeal-conference.eu
9. Agnieszka Tomala, Julia Sadlik, Edyta Kosińska, Magdalena Bańkosz , “Gradient bone mimicking Ti/HAp composites.”, 5th International Conference Strategies toward Green Deal Implementations Water, Raw Materials & Energy, 27.11-29.11.2024, Kraków/online, plakat, https://www.greendeal-conference.eu
10. Agnieszka Tomala, „Next generation of porous, gradient, bio-active and laser textured Ti/HAp composite biomaterials “, Life Science Open Space, 28.11 - 29.12.2024, Krakow Technology Park, Krakow, Presentation, https://lsos.info
11. Scientific symposium during the M-ERA.NET3/2022/48/BiLaTex/2023 project meeting - September 17, 2024 - September 19, 2024, presentations by all PhD students employed in the project at Tallinn University of Technology, Tallinn, Estonia.
12. Agnieszka Sobczak Kupiec delivered a lecture on projects conducted in the research group "biomaterials" during the conference "Become a Researcher"on October 30, 2024, at the Cracow University of Technology. The organizing committee promoted the event to encourage women in science, supported by the Deputy Minister of Science and Higher Education, Professor Maria Mrówczyńska, Ph.D. Eng.
13. Julia Sadlik, Edyta Kosińska, Agnieszka Tomala , “Metalurgia proszków jako proces wytwarzania gradientowych kompozytów tytanowo-ceramicznych.”, XV Jubileuszowa Konferencja Tytan i Jego Stopy 2025, 04.05.2025 - 07.05.2025, Rytro, poster, https://tytan25.agh.edu.pl
14. Edyta Kosińska, Julia Sadlik, Agnieszka Tomala , “Kompozyty na bazie tytanu z dodatkiem hydroksyapatytu pod zastosowania na implanty kostne.", XV Jubileuszowa Konferencja Tytan i Jego Stopy 2025, 04.05.2025 - 07.05.2025, Rytro, poster, https://tytan25.agh.edu.pl
15. Agnieszka Tomala, Julia Sadlik, Edyta Kosińska, Magdalena Bańkosz, “Gradientowe Kompozyty Ti/HAp”, XV Jubileuszowa Konferencja Tytan i Jego Stopy 2025, 04.05.2025 - 07.05.2025, Rytro, Poland, Presentation, https://tytan25.agh.edu.pl
16. Agnieszka Tomala, Plenary session during the Modern Materials and Manufacturing (MMM2025) dedicated to the BiLaTex project: “Gradient, bioactive and laser textured Ti/HAp implants,” presentation May 6-8, 2025 https://taltech.ee/en/mmm2025
17. 5. Rezapourian, M., & Hussainova, I. (2025). Mechanical analysis of multi-surface TPMS lattices for bone applications. Modern Materials and Manufacturing (MMM2025) conference in Tallinn, presentation May 6-8, 2025 https://taltech.ee/en/mmm2025
18. Agnieszka Tomala "Innowacyjny biomateriał kompozytowy Ti/HAP dla medycyny regeneracyjnej" presentation during International Conference STEAM & AI in EDUCATION, June 9–11 2025, Kraków, Poland https://saie.it.pk.edu.pl/