Title: NEW GENERATION OF BIOACTIVE LASER TEXTURED TI/HAP IMPLANTS
Acronym: BiLaTex
start-end date:
01/05/2023 – 30/04/2026
Total Project Costs: 765 000 (Euro)
Acknowledgements: The partners gratefully acknowledge financial support of the project “New Generation of Bioactive Laser Textured Ti/Hap Implants” under acronym “BiLaTex” carried out within M-ERA.NET 3 Call 2022 programme.
Project co-financed by the National Center for Research and Development under the program M-ERA.NET 3 Call 2022 under registration number ERA.NET3/2022/48/BiLaTex/2023.
Project Abstract
Visible effects of society’s ageing is the reported increase in the necessity of orthopaedic implants boosting to a huge economical market. For a successful integration of any implant, bone regeneration, osseointegration at the interface bone and implant as well as mitigating inflammatory events are crucial aspects. The project aims at extending the biocompatibility and tribo-mechanical performance associated with a lifetime of surgical implants based on Titanium (Ti). The hypothesis states combining Ti alloy with hydroxyapatite (HAp), and medically active components (drug delivery function) in order to obtain excellent biomaterial supporting bone growth and eliminating the problem of loosening of the implant by its integration with bone. The project goes beyond the state-of-the-art by laser surface treatment, opening the underlying porosity improving the cell transport and cell growth. The result implant biomaterial, will reduce the number of removal surgeries in the future.
Partners:
Coordinator – Cracow University of Technology (PK) ![]()
Contact person (Principal Investigator):
Dr inż. Agnieszka Maria Tomala
Faculty of Materials Engineering and Physics37 Jana Pawla II, 31-864 Cracow, Poland
Tel.: +48 12 628 34 62
e-mail: agnieszka.tomala@pk.edu.pl
Researchers Involved:
Prof. dr hab. inż. Agnieszka SOBCZAK-KUPIEC (agnieszka.sobczak-kupiec@pk.edu.pl),
dr hab. inż. Bożena Tyliszczak (bozena.tyliszczak@pk.edu.pl),
mgr inż. Julia Sadik (ulia.sadlik@doktorant.pk.edu.pl),
mgr inż. Magdalena Bańkosz (magdalena.bankosz@pk.edu.pl)
mgr inż. Edyta Kosińska (edyta.kosinska@doktorant.pk.edu.pl)
Tallinn University of Technology (TalTech) ![]()
Contact person: DSc Irina Hussainova, Tenured Full Professor
Department of Mehanical and Industrial Engineering,
Tallinn University of Technology
Ehitajate 5, 19086, Tallinn, Estonia
Office: U06-205
Tel.: 372 6203371
e-mail: irina.hussainova@taltech.ee
Researchers Involved:
Rahul Kumar (rahul.kumar@taltech.ee)
Mansoureh Rezapourianghahfarokhi (mansoureh.rezapourianghahfarokhi@taltech.ee )
University of Ljubljana (UL) ![]()
Contact person: University of Ljubljana
Faculty of Mechanical Engineering TINT – Laboratory for Tribology and Interface Nanotechnology
Aškerčeva 6, 1000 Ljubljana
Tel.: +386 1 4771 460
e-mail: Mitjan.Kalin@fs.uni-lj.si
Researchers Involved:
doc. dr. Marko Polajnar (marko.polajnar@fs.uni-lj.si)
ATMAT Sp. z o.o. (ATMAT) ![]()
Contact person: Mateusz Dyląg
ATMAT Sp. z o.o.
Ul. Leśna 28, 32-590 Libiąż
email: mateusz.dylag@atmat.pl
mobile: +48 501 256 670
Researchers Involved:
Jarosław Wołek (jaroslaw.wolek@atmat.pl)
Meetings:
1st kick-off meeting (on-line): 11.05.2023
2nd meeting (on-line): 28.09.2023
3rd meeting (on-line): 22.02.2024
4th meeting (on-line): 14.06.2024
5th meeting (at TalTech): 18-19. 09.2024
6th meeting (on-line): 10.01.2025
Download Meeting FILES
Publications:
1. Rezapourian, Mansoureh; Hussainova, Irina. Optimal mechanical properties of Hydroxyapatite gradient Voronoi porous scaffolds for bone applications — A numerical study. Journal of the Mechanical Behavior of Biomedical Materials, 2023, 106232, https://doi.org/10.1016/j.jmbbm.2023.106232
2. Kumar, R.; Rezapourian, M.; Rahmani, R.; Maurya, H.S.; Kamboj, N.; Hussainova, I. Bioinspired and Multifunctional Tribological Materials for Sliding, Erosive, Machining, and Energy-Absorbing Conditions: A Review. Biomimetics 2024, 9, 209.https://doi.org/10.3390/biomimetics9040209
2. Kumar, R.; Rezapourian, M.; Rahmani, R.; Maurya, H.S.; Kamboj, N.; Hussainova, I. Bioinspired and Multifunctional Tribological Materials for Sliding, Erosive, Machining, and Energy-Absorbing Conditions: A Review. Biomimetics 2024, 9, 209.https://doi.org/10.3390/biomimetics9040209
3. Rezapourian, M., Kumar, R., & Hussainova, I. (2024). Effect of unit cell rotation on the mechanical performance of selective laser melted Gyroid structures for bone tissue engineering. Progress in Engineering Science, 1(2-3), 100011. https://doi.org/10.1016/j.pes.2024.100011
Paper in progress:
• Julia Sadlik, Edyta Kosińska, Magdalena Bańkosz, Agnieszka Tomala, Grzegorz Bruzda, Josef Jampilek, Agnieszka Sobczak-Kupiec
"Gradient Titanium Alloy With Bioactive Hydroxyapatite Porous Structures for Bone Regeneration"
International Journal of Molecular Sciences, Manuscript ID: ijms-3160162
• Rezapourian, M., Cheloee, A., Schmauder, S., & Hussainova, I., (2023), Implementing machine learning algorithms on predicting mechanical properties of TMPS cellular lattices for critical size defects in load-bearing applications.
• Experimental and numerical analysis of energy absorption capacity of SLM-ed Ti6Al4V multi-morphology TPMS
• Review paper: Optimization, Design, and Biocompatibility of TPMS in Bone Replacement: Bridging Mechanical and Biological Requirements
Conferences:
1. Julia Sadlik “The Methods of Obtaining of Titanium-Hydroxyapatite Composites”, 32nd Annual Conference Biomaterials in Medicine and Veterinary Medicine, 12-15.X.2023r Rytro, Polska. PLAKAT https://www.biomat.agh.edu.pl/2023
2. Agnieszka Maria Tomala „HAp Powder as a Carrier of Biologically Active Substances”, 32nd Annual Conference Biomaterials in Medicine and Veterinary Medicine, 12-15.X.2023r Rytro, Polska. PLAKAT https://www.biomat.agh.edu.pl/2023
2. Agnieszka Maria Tomala „HAp Powder as a Carrier of Biologically Active Substances”, 32nd Annual Conference Biomaterials in Medicine and Veterinary Medicine, 12-15.X.2023r Rytro, Polska. PLAKAT https://www.biomat.agh.edu.pl/2023